Clavomax Side Effects

Clavomax is generally well tolerated. The majority of side effects reported are of mild to transient action and less than 3% of patients discontinued therapy because of drug related effects. Common adverse effects are as follows: Gastrointestinal: diarrhea, nausea, vomiting, indigestion, gastritis, stomatitis, glossitis, black hairy tongue, enterocolitis, mucco cutaneous candidiasis and pseudomembraneous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.
Hypersensitivity reactions: skin rashes, pruritis, urticaria, angioedema, serum sickness-like reactions, erytheme multiforme (rarely Stevens Johnson Syndrome) and an occasional case of exfoliative dermatitis (including toxic epidermal necrolysis) have been reported. These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur the drug should be discontinued. Serious and occasionally fatal hypersensitivity (anaphylactic) reactions can occur with oral penicillin products.
Liver: a moderate rise in AST (SGOT) and/or ALT (SGTP) has been noted in patients with ampicillin class antibiotics, but the significance of these findings is unknown. Hepatic dysfunction, including increase in serum transaminases (AST and/or ALT), serum bilirubin and/or alkaline phosphatase, has been infrequently reported with amoxicillin. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic-hepatocellular changes. The onset of signs/symptoms of hepatic dysfunction may occur during or several weeks after therapy has been discontinued. The hepatic dysfunction, which may be severe, is usually reversible. On rare occasions, death have been reported (less than 1 death reported per estimated 4 million prescriptions worldwide). These have generally been cases associated with serious underlying diseases or concomitant medications.
Renal: Interstitial nephritis and heamaturia have rarely been reported.
Haemic and Lymphatic systems: anemia, thrombocytopenia, thrombocytopenic purpurea, eosinophilia, leucopenia and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensivity phenomena. A slight thrombocytosis was noted in less than 1% of patients treated with the combination of amoxicillin with clavulanic acid.
Central Nervous System: reversible hyperactivity, agitation, anxiety, insomnia, confusion, behavioral changes, and/or dizziness have been rarely reported.
Skin subcutaneous tissue disorders: Frequency 'very rare': Drug Reaction with Eosinophilia and System Symptoms (DRESS).