Cetrizet D Drug Interactions

Cetirizine Hydrochloride: As cetirizine is only minimally metabolised, being excreted unchanged primarily via the kidneys, it may have a low potential for adverse drug reactions involving or inhibition metabolic enzyme systems.
Potentially hazardous interactions: There are no reports of hazardous interactions with other drugs to date. Concomitant administration with alcohol or diazepam does not impair psychomotor performance any more than the impairment of performance produced by alcohol alone. Nevertheless, caution is recommended if sedatives are also being taken. Allergy skin tests are inhibited by antihistamines and an appropriate wash out period is required before performing them.
Pseudoephedrine Hydrochloride: Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis; use of Cetrizet-D is therefore to be avoided in digitalized patients. Antacids increase the rate of pseudoephedrine absorption; kaolin decreases it. Concomitant use of pseudoephedrine with other sympathomimetic agents such as decongestants, tricyclic antidepressants, appetite suppressants and amphetamine-like psychostimulants or with monoamine oxidase inhibitors, which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure. Interaction with MAO inhibitor is still possible for up to 15 days after stopping treatment due to the long duration of action of MAO inhibitor.
The effect of antihypertensive agents which interfere with sympathetic activity may be partially reversed by pseudoephedrine, e.g., bretylium, bethanidine, guanethidine, reserpine, debrisoquine, methyldopa, alpha and beta-adrenergic blocking agents.