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No interaction studies have been performed with Levocetirizine (including no studies with CYP3A4 inducers); studies with the racemate compound Cetirizine demonstrated that there were no clinically relevant adverse interactions (with antipyrine, Pseudoephedrine, Cimetidine, Ketoconazole, Erythromycin, Azithromycin, Glipizide and Diazepam).
Theophylline: A small decrease in the clearance of Cetirizine can be observed with Theophylline (400 mg once a day); while the disposition of Theophylline cannot be altered by concomitant Cetirizine administration.
Ritonavir: The extent of exposure to Cetirizine is possible to increase while the disposition of Ritonavir can be slightly altered further to concomitant Cetirizine administration.
Food: The extent of absorption of Levocetirizine is not reduced with food, although the rate of absorption is decreased.
Alcohol: The concurrent administration of Cetirizine or Levocetirizine and alcohol or other CNS depressants may cause additional reductions in alertness and impairment of performance.
