Management of acute pain in adults & treatment of primary dysmenorrhea. Relief of acute & chronic pain & inflammation of RA & OA. Relief of signs & symptoms of ankylosing spondylitis. 200 mg: Management of low back pain.
AdultAcute pain & primary dysmenorrheaInitially 400 mg, followed by 200 mg if needed on 1st day. Subsequently, 200 mg bd as needed. AS 200-400 mg daily. OA 200 mg once daily. RA 200 mg bd. Low back pain 200 mg once daily or 100 mg bd.
View Celebrex overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to celecoxib or sulfonamides. Patients who have experienced asthma, urticaria or allergic-type reactions after taking aspirin or NSAIDs, including other COX-2 inhibitors. Peri-op pain treatment in CABG, established CV disease (ischemic heart disease & stroke).
Discontinue use at 1st appearance of skin rash, mucosal lesions or any other signs of hypersensitivity. Not a substitute for ASA for prophylaxis of CV thromboembolic disease. Increased risk of serious CV thrombotic events, MI & stroke. Patients w/ prior history of or active GI disease eg, ulceration, bleeding or inflammation or other risk factors associated w/ PUD eg, alcoholism, smoking or corticosteroid therapy. Heart disease, HTN, hyperlipidaemia, DM, peripheral arterial disease; CHF; compromised cardiac function, preexisting edema or other conditions predisposed to or worsened by fluid retention or at risk of hypovolemia. Serious skin infections eg, exfoliative dermatitis, SJS & TEN. Patients who are known or suspected to be CYP2C9 poor metabolizers. Ensure adequate hydration. Avoid concomitant use w/ non-aspirin NSAIDs. Concomitant use w/ oral anticoagulants. Not recommended w/ severe hepatic impairment. Moderate hepatic impairment (Child-Pugh class B). Advanced renal disease; severe renal impairment. Avoid use during 2nd or 3rd trimester of pregnancy. Lactation. Not to be used in childn. Elderly or debilitated patients.
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