Cefper Dosage/Direction for Use

Adult: Usual dose: 2-4 g/day of the 1:1 ratio (ie, cefoperazone 1-2 g/day) given IV or IM equally divided dose every 12 hrs.
In severe infection, the daily dose may be increased to 8 g/day of the 1:1 ratio (ie, cefoperazone 4 g/day).
Use in children: Usual dose is 40-80 mg/kg/day of the 1:1 ratio (ie, cefoperazone 20-40 mg/kg/day) given IV or IM equally divided dose every 6-12 hrs.
In serious or refractory infection, the daily dose may be increased to 160 mg/kg/day of the 1:1 ratio (ie, cefoperazone 80 mg/kg/day).
The recommended maximum daily dose of sulbactam is 4 g.
IV administration: Intermittent injection: Reconstituted each vial with sterile water for injection to volume 4 ml and then dilute to 20 ml followed by administration for 15-60 minutes.
Reconstituted solution should keep in room temperature not exceeding 30°C not more than 24 hrs or in temperature 2-8°C not more than 5 days.
IV injection: Each vial should be reconstituted as mentioned previously and administered over a minimum of 3 minutes.
IM administration: Lidocaine HCl 2% is a suitable vehicle for IM administration, however, not for initial reconstitution.
Dosage in Renal dysfunction: Patients with creatinine clearance 15-30 ml/min should receive the maximum dose of 1 g sulbactam every 12 hrs. Patients with creatinine clearance <15 ml/min should receive the maximum dose of 500 mg every 12 hrs. In severe infection may be separately adding dose of cefoperazone.
Dosage in Hepatic dysfunction: Cefoperazone is mainly excreted in bile. Dose modification may be necessary in case of severe biliary obstruction, severe hepatic disease or concomitant with renal dysfunction. In these cases, the dose of cefoperazone should not exceed 2 g/day.