Calcium lactate

Calcium lactate Should be taken with food.

Conditions associated with hypercalcaemia or hypercalciuria.

Patient with achlorhydria, hypoparathyroid disease, sarcoidosis, history of nephrolithiasis. Renal impairment. Pregnancy and lactation.

Significant: Gastrointestinal effects (e.g. constipation, bloating, gas); hypercalcaemia, hypercalciuria (particularly in hypoparathyroid patients receiving high doses of vitamin D).
Cardiac disorders: Cardiac arrhythmias.
Gastrointestinal disorders: Nausea, vomiting, abdominal pain.
Metabolism and nutrition disorders: Anorexia, thirst.
Musculoskeletal and connective tissue disorders: Muscle weakness.
Nervous system disorders: Coma.
Psychiatric disorders: Confusion.
Renal and urinary disorders: Renal calculi, nephrocalcinosis, polyuria.

IM/Parenteral: C

Monitor serum calcium levels.

Symptoms: Anorexia, extreme thirst, lassitude, nausea, vomiting, headache, vertigo, increased blood urea, increased cholesterol levels, calcium deposition in tissues including the kidneys and arteries, cardiac arrhythmias, bradycardia.

Management: Supportive and symptomatic treatment. Administer NaCl 0.9% via IV infusion to treat severe hypercalcaemia. May give a loop diuretic to increase urinary calcium excretion; if ineffective, may administer IV calcitonin or consider bisphosphonates, plicamycin, or corticosteroids. In severe cases, peritoneal dialysis may be employed to remove excess calcium. Avoid exposure to direct sunlight.

May reduce the absorption of tetracyclines, bisphosphonates (e.g. alendronate, ibandronate), fluoride, and certain fluoroquinolones (e.g. ciprofloxacin). Reduced absorption with corticosteroids. May enhance the cardiac effects and precipitate toxicity of cardiac glycosides (e.g. digoxin). Increased absorption with vitamin D.

Description:
Mechanism of Action: Calcium lactate helps prevent or correct negative serum calcium balance. Calcium from calcium salts regulates nerve and muscle activity and supports normal cardiac function.
Pharmacokinetics:
Absorption: Absorbed mainly from the small intestine via active transport and passive diffusion.
Distribution: Crosses the placenta and enters breast milk. Plasma protein binding: 5%.
Excretion: Mainly via faeces (as unabsorbed calcium).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 13144, Calcium Lactate. https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-Lactate. Accessed Sept. 25, 2025.

Store at or below 30°C. Protect from light and moisture.

Calcium/with Vitamins

A12AA05 - calcium lactate ; Belongs to the class of calcium-containing preparations. Used as dietary supplements.

Brayfield A, Cadart C (eds). Calcium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/09/2025.

Calcium Lactate Tablets BP 300 mg (Accord-UK Ltd). MHRA. https://products.mhra.gov.uk. Accessed 04/09/2025.

Calcium Lactate. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/09/2025.

Calcium Salts. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/09/2025.

Joint Formulary Committee. Calcium Lactate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/09/2025.

SW Calcium Lactate 300 mg Tablet (Sunward Pharmaceutical Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 04/09/2025.