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Symptoms: Excessive prolonged use of topical corticosteroids can suppress pituitary-adrenal function resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease.
A single overdosage of gentamicin would not be expected to produce symptoms.
Treatment: Appropriate symptomatic treatment of corticosteroids overdosage is indicated. Acute hypercorticoid symptoms are virtually reversible. Treat electrolyte imbalance, if necessary. In cases of chronic toxicity, slow withdrawal of corticosteroids is advised.
Although a single overdose is not expected to require treatment, gentamicin can be removed from the blood by hemodialysis or peritoneal dialysis. Approximately 80-90% is removed from the circulatory system during 12 hrs of hemodialysis. Peritoneal dialysis appears to be less effective.
