Azicine Dosage/Direction for Use

Administration: Azicine is administered orally, should be taken at least 1 hour before or 2 hours after food.
Dosage: Adults: For the treatment of sexually transmitted diseases caused by Chlamydia trachomatis, Haemophilus ducreyi or susceptible Neisseria gonorrhoea, the dose is 1000 mg as a single oral dose.
For all other indications in which the oral formulation is administered, the total dosage of 1500 mg should be given as 500 mg daily for 3 days. As an alternative, the same total dose can be given over 5 days with 500 mg given on day 1, then 250 mg daily on days 2 to 5.
For prophylaxis against MAC infections in patients infected with the human immunodeficiency virus (HIV), the dose is 1200 mg once per week.
For the treatment of DMAC infections in patients with advanced HIV infection, the recommended dose is 600 mg once a day. Azithromycin should be administered in combination with other antimycobacterial agents that have shown in vitro activity against MAC, such as ethambutol at the approved dose.
In children under 45 kg body weight: Azithromycin capsules are not suitable for children under 45 kg.
Elderly: The same dosage as in adult patients is used in the elderly.
Patients with renal impairment: No dose adjustment is necessary in patients with mild to moderate renal impairment (glomerular filtration rate 10 - 80 ml/min). Caution should be exercised when azithromycin is administered to patients with severe renal impairment (glomerular filtration rate < 10 ml/min).
Patients with hepatic impairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment.