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Hypersensitivity to the active substances, to any of the excipients listed in Description.
Hypersensitivity to other beta-blockers.
Hypersensitivity to sulphonamides (see Precautions).
Reactive airway disease including bronchial asthma or a history of bronchial asthma, or severe chronic obstructive pulmonary disease.
Sinus bradycardia, sick sinus syndrome, sino-atrial block, second- or third-degree atrioventricular block not controlled with pace-maker. Overt cardiac failure, or cardiogenic shock.
Severe allergic rhinitis.
Hyperchloraemic acidosis (see Dosage & Administration)
Severe renal impairment.
