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Pharmacology: Pharmacodynamics: Mechanism of Action: Mometasone furoate is a topical glucorticosteroid with local antiinflammatory properties. Mechanism for the antiallergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of allergic reactions. Mometasone furoate significantly inhibits the release of leukotrienes from leukocytes of allergic patients. In addition, it is an extremely potent inhibitor of the production of the Th2 cytokines IL-4 and IL-5 from human CD4+ T-cells.
Pharmacokinetics: Mometasone furoate, administered as a nasal spray, has negligible (≤0.1%) systemic bioavailability and is generally undetectable in plasma, despite the use of a sensitive assay with a lower quantitation limit of 50pg/ml: thus there are no relevant pharmacokinetic data for this dosage form. Mometasone furoate suspension is very poorly absorbed from the gastrointestinal tract, and the small amount that may be swallowed and absorbed undergoes extensive first-pass metabolism prior to excretion mostly as metabolites in the bile and to a limited extent in the urine.
