For oral administration only. Axcel Azithromycin-500mg Tablet should be administered as a single daily dose. The period of dosing with regard to infection is given as follows. It can be taken with or without food.
Adults: For the treatment of sexually transmitted diseases caused by Chlamydia trachomatis and Haemophilus ducreyi, the dose is 1000mg as a single oral dose. For susceptible Neisseria gonorrhoeae, the dose is 1000mg or 2000mg of azithromycin in combination wiith 250mg or 500mg ceftriaxone according to local clinical treatment guidelines. For patients who are allergic to penicillin and/or cephalosporins, prescribers should consult local treatment guidelines. For all other indications in which the oral formulation is administered, the total dosage of 1500mg shoud be given as 500mg daily for 3 days. As an alternative, the same total dose can be given over 5 days with 500mg given on Day 1, then 250mg daily on Days 2 to 5.
Children: The maximum recommended total dose for any treatment is 1500mg for children. Axcel Azithromycin-500mg Tablet should only be administered to children weighing more than 45kg, with the same dosage used as in adult patients.
Special populations: In the Elderly: The same dosage as in adult patients is used in the elderly. Elderly patients may be more susceptible to the development of torsades de pointes arrhythmia than younger patients.
In Patients with Renal Impairment: No dose adjustment is necessary in patients with mild to moderate renal impairment (GFR 10-80 ml/min). Caution should be exercised when azithromycin is administered to patients with severe renal impairment (GFR <10ml/min).
In Patients with Hepatic lmpairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment.