Choline salicylate, benzalkonium chloride, lidocaine hydrochloride.
Light brown coloured gel with a pleasant flavour.
Avo Liquid Gel contains: Choline Salicylate Solution equivalent to Choline Salicylate 8.7% w/w, Benzalkonium Chloride Solution 0.01% w/w, Lidocaine Hydrochloride 2% w/w.
Pharmacology: Pharmacodynamics: Choline salicylate is the choline salt of salicylic acid and its pharmacology is essentially that of salicylic acid. It has exhibited anti-inflammatory analgesic and antipyretic actions in animal models, and is taken orally or is applied topically in man for the relief of pain and inflammation. Like salicylic acid, it has no antithrombotic activity and shows a low potential for production of gastrointestinal injury when given by the oral route. The pharmacological actions of choline salicylate are thought to be primarily mediated through inhibition of prostaglandin production, although effects on lukotriene pathways, kinin release and nerve conduction have been proposed.
Pharmacokinetics: Choline salicylate is absorbed from the gut and is likely to be absorbed across mucous membranes such as all buccal mucosa. Metabolism of salicylic acid is by glycine and phenolic or acyl glucuronate conjugation with small amounts undergoing hydroxylation. The plasma half-life of salicylic acid is 2-4 hours. Both metabolites and a small amount of intact salicylic acid are excreted, mainly in the urine. Salicylic acid is highly (80-90%) protein bound and although it has a low apparent volume of distribution of around 0.151 l/kg it is widely distributed throughout extracellular water and most tissues.
For the temporary relief of pain caused by recurrent mouth ulcers, denture irritation.
Adults and the elderly: apply a small amount to the affected area with a clean fingertip. One application should be sufficient. Use up to four times a day.
Salicylate toxicity can result if the stated dose is exceeded.
The usual procedure for salicylate overdosage should be followed, including general supportive measures and gastric lavage if necessary.
Hypersensitivity to any of the ingredients of the formula.
Allergic to salicylates eg: Aspirin; Allergic to lignocaine.
Active peptic ulcer.
Herpes infection and influenza in childhood.
Not recommended below 4 months old child.
Bronchial asthma.
Keep the tube tightly closed after use.
Prolonged use without medical supervision is harmful.
Do not exceed the recommended dose.
Use in Children: Keep out of reach of children.
There is clinical evidence of the safety of salicylates in pregnancy, but they may prolong bleeding and contribute to maternal and neonatal bleeding, and are best avoided at term.
This medicine may pass into breast milk in very small amounts, but is unlikely to have any adverse effects on a nursing infant.
Advised to consult a doctor before using the product.
Excessive application or confinement under a denture irritates the mucosa and this can itself cause ulceration.
Salicylates may enhance the effect of anticoagulants and inhibit the action of uricosurics.
Store below 30°C. Protect from light.
A03AB - Synthetic anticholinergics, quaternary ammonium compounds ; Used in the treatment of functional bowel disorders.
Avo Liquid oral gel
15 g x 1's
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