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Symptoms and signs: There is currently no experience of overdose with APRETUDE.
Treatment: There is no specific treatment for overdose with APRETUDE. If overdose occurs, the individual should be treated supportively with appropriate monitoring as necessary. Further management should be as clinically indicated or as recommended by the national poisons centre, where available.
Cabotegravir is known to be highly protein bound in plasma; therefore, dialysis is unlikely to be helpful in removal of drug from the body. Management of overdose with APRETUDE injection should take into consideration the prolonged exposure to drug following an injection (see Precautions).
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