Alovasc Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amlodipine

Indications/Uses

1st-line treatment of HTN & myocardial ischemia whether due to fixed obstruction (stable angina) &/or vasospasm/vasoconstriction (Prinzmetal's or variant angina) of coronary vasculature. Monotherapy or in combination w/ other antianginal drugs in patients w/ angina refractory to nitrates &/or β-blockers.

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Dosage/Direction for Use

Adult Initially 5 mg once daily, may be increased to max: 10 mg.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to amlodipine or dihydropyridines. Cardiogenic shock, clinically significant aortic stenosis, unstable angina (excluding Prinzmetal's angina).

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Special Precautions

Hypertensive crisis; CHF. May affect ability to drive & use machines. Hepatic impairment. Pregnancy & lactation. Not recommended in childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Oedema. Somnolence, dizziness, headache; visual disturbance; palpitations; flushing; dyspnoea; abdominal pain, nausea, dyspepsia, altered bowel habits; ankle swelling, muscle cramps; fatigue, asthenia.

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Drug Interactions

Increased risk of hypotension w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, macrolides (ie, erythromycin, clarithromycin), verapamil, diltiazem. Varied plasma conc w/ strong CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Increased BP-lowering effects w/ grapefruit or grapefruit juice. Additive BP-lowering effects of other anithypertensives. Increased tacrolimus blood levels. Increased exposure of mechanistic target of rapamycin inhibitors eg, sirolimus, temsirolimus, everolimus. Increased trough conc of cyclosporin. Increased exposure to simvastatin.

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Storage

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Description

View Alovasc description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Calcium Antagonists / Anti-Anginal Drugs

ATC Classification

C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Alovasc tab 10 mg

Packing/Price

30's

Form

Alovasc tab 5 mg

Packing/Price

30's

Alovasc

amlodipine

Manufacturer:

Aeva

Distributor:

Apex