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No formal interaction studies with ACTILYSE and medicinal products commonly administered in patients with acute myocardial infarction have been performed.
Drugs affecting coagulation/platelet function: The risk of haemorrhage may be increased with the use of coumarin derivatives, direct oral anticoagulants, antiplatelet aggregation agents, heparin or any other agent which influences haemostasis (before, during or within the first 24 hours after treatment with ACTILYSE). Treatment with these products should be avoided in the first 24 hours after treatment for acute ischaemic stroke (see Dosage & Administration).
ACE inhibitors: Concomitant treatment with ACE inhibitors may enhance the risk of suffering a hypersensitivity reaction (see Precautions).
