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Hypersensitivity to the active substances or to any of the excipients listed in Description.
Pregnancy, breast-feeding and in women of childbearing potential not using appropriate contraceptive measures (see Use in Pregnancy & Lactation).
Active liver disease or unexplained persistent elevations in serum transaminases and any serum transaminase elevation exceeding 3x the upper limit of normal (ULN) (see Precautions).
In patients with severe renal impairment (creatinine clearance <30 ml/min) (see Precautions).
In patients with myopathy (see Precautions).
In patients receiving concomitant ciclosporin (see Interactions).
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