Vopicain should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics since the toxic effects of these drugs could be additive. Vopicain should be used with caution in patients receiving anti-arrhythmic agents with local anesthetics activity e.g, mexilitine, or class III anti-arrhythmic agents since their use may be additive.