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Symptoms: Over dose of Volteri Tablets may cause marked decrease in blood pressure, including shock, and reflex tachycardia.
Treatment: Cardiac and respiratory function should be monitored and blood pressure should be measured frequently. If marked decrease in blood pressure occur, provide cardiovascular support including elevation of the extremities and the administration of fluids. If the symptom does not improve, administration of vasopressors should be considered with careful attention to circulating blood volume and urine output. Since candesartan and amlodipine, components of Volteri Tablets, have high protein binding rates, hemodialysis is not effective for elimination. Charcoal administration is reported to be effective for inhibition of absorption since AUC of amlodipine decreased when activated charcoal was administered immediately after the use of amlodipine and 2 hours after the use of amlodipine, respectively.
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