Vocinti Drug Interactions

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Full Prescribing Info

Drug Interactions

Administration of vonoprazan results in elevation of intragastric pH, suggesting that it may interfere with the absorption of drugs where gastric pH is an important determinant of oral bioavailability. Use of vonoprazan is therefore not recommended with some of these drugs for which absorption is dependent on acidic intragastric pH such as atazanavir and nelfinavir, due to significant reduction in their bioavailability.
VOCINTI Tablets are metabolized mainly by hepatic drug-metabolizing enzyme CYP3A4 and partially by CYP2B6, CYP2C19 and CYP2D6.
Gastric antisecretory effect of VOCINTI Tablets may promote or inhibit absorption of concomitant drugs. Use of vonoprazan is therefore not recommended with some of these drugs for which absorption is dependent on acidic intragastric pH. (See Tables 17 and 18.)

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vonoprazan

Manufacturer:

Takeda

Marketer:

Wellesta