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Hypersensitivity to the active substance or to any of the excipients.
Hepatic impairment (i.e. cirrhosis or active liver disease) or transaminases exceeding 3 X upper limit of normal (see Dosage & Administration and Precautions).
Concomitant use of potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin) (see Interactions).
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