Trilaciclib - Intravenous

Trilaciclib is used to prevent bone marrow depression (a condition in which the blood cells are low) in adults who are receiving chemotherapy for a certain type of lung cancer.

Trilaciclib injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.

The dose of Trilaciclib will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your condition, the effectiveness of therapy and your response to the medication.

Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Trilaciclib.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.

Do not use Trilaciclib if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any of its ingredients.

Do not use this medicine if you are pregnant. If you become pregnant while on Trilaciclib therapy, alert your doctor immediately. This medicine may cause harm to your unborn child.

It is important that you do not get pregnant while using this medicine. You must use proven birth control methods during Trilaciclib therapy and for at least 3 weeks after stopping the treatment.

Do not breastfeed while you are being treated with this medicine and for at least 3 weeks after the last dose.

Inform your doctor if you have moderate to severe liver disease.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

• Pregnancy tests must be done before treatment to know if this medicine is suited for you to use.
• Regular monitoring of signs of infusion site reactions, allergic reactions, and lung problems may also be needed.

Trilaciclib may cause any of the following side effects: stomach pain, headache, tiredness, rash, and swelling of the ankles, feet or hands.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

• signs and symptoms of allergic reaction e.g. rashes, breathlessness, swelling of the face, eyes or mouth
• signs and symptoms of lung problems e.g. dry cough, shortness of breath, difficulty breathing, extreme tiredness, loss of appetite, unexplained weight loss, chest discomfort
• pain, redness, swelling, or any other reactions at the site of infusion

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Inform your doctor and pharmacist if you are taking or using any of these medicines:

• dofetilide (medicine for irregular heartbeat)
• dalfampridine (medicine used to improve walking in people with multiple sclerosis [scars or lesions in the brain and spinal cord])
• cisplatin (medicine for cancer)

This list does not include all medicines that may interact with Trilaciclib.

Always notify your doctor and pharmacist if you are taking or using any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.

Avoid alcohol.

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As Trilaciclib is a cancer medicine, always return any unused or expired medicine to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.