Tarivid Special Precautions

Beta-lactamase production should have no effect on ofloxacin activity. Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection, and to determine their susceptibility to ofloxacin. Therapy with ofloxacin may be initiated before results of these tests are known; once results become available, appropriate therapy should be continued.
As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with ofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance. If anaerobic organisms are suspected of contributing to the infection, appropriate therapy for anaerobic pathogens should be administered.
Note: Although treatment of infections due to this organism in this infection demonstrated a clinically acceptable overall outcome, efficacy was demonstrated in fewer than 10 infections.
Ofloxacin has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high doses for short periods of time to treat gonorrhoea may mask or delay the symptoms of incubating syphilis. All patients with gonorrhoea should have a serologic test for syphilis at the time of diagnosis. Patients treated with ofloxacin should have a follow-up serologic test for syphilis after 3 months.
As with other quinolones, disturbances of blood glucose, including symptomatic hyper- and hypoglycaemia, have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycaemic agents or with insulin. In these patients, careful monitoring of blood glucose is recommended. If a hypoglycaemic reaction occurs in patient being treated with ofloxacin, discontinue ofloxacin immediately and consult a physician.
Patients who are being treated with Tarivid IV should not expose themselves unnecessarily to strong sunlight and should avoid ultraviolet rays (sunray lamp, solarium).
Effects on the Ability to Drive or Operate Machinery: Even if used in accordance with the directions, ofloxacin may affect alertness and reaction time to such an extent that ability to drive, cross the road safe or operate machinery may be impaired. Concurrent use of alcohol increases this risk.