The most common side effect is constipation. Some patients require a temporary decrease in dosage or discontinuation of therapy.
Other side effect is abdominal discomfort, flatulence, nausea, vomiting, diarrhea, heartburn, anorexia, steatorrhea, rash and irritation on skin, tongue and perianal area.
Hematologic: prolonged prothrombin time ecchymosis or anemia.
Gastrointestinal: GI rectal bleeding, black stool/s, hemorrhoidal bleeding, ulcer attack, sour taste, pancreatitis, rectal pain or diverticulitis.
Hypersensitivity: urticaria, asthma, wheezing or shortness of breath.
Musculoskeletal: backache, muscle and joint pains or arthritis.
Neurologic: headache, anxiety, vertigo, dizziness, fatigue, tinnitus, syncope, drowsiness, femoral nerve pain.
Eye: uveitis.
Renal: hematuria, dysuria, diuresis.
Miscellaneous: weight loss, weight gain, increase libido, swollen glands, edema or dental bleeding.
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