Sanfuracil Dosage/Direction for Use

SANFURACIL injection is for i.v. use only, and no dilution is required. Actual body weight is used for dosage calculation, except in obese patients and in the presence of abnormal fluid retention (oedema, ascites), the estimated lean body mass is used.
Usual dosage: 12 mg/kg i.v. once daily for 4 successive days. The maximum daily dose is 800 mg. If no toxicity is observed, 6 mg/kg are given on days 6, 8, 10 and 12 (no therapy is given on days 5, 7, 9 and 11). Therapy is discontinued at the end of day 12, even if no toxicity is observed.
Poor risk patients or those with inadequate nutritional state: 6 mg/kg/day for 3 days. If no toxicity is observed, 3 mg/kg are given on days 5, 7 and 9 (no therapy on days 4, 6 and 8). The maximum daily dose is 400 mg. The above sequence of injections constitutes a "course of therapy".
Maintenance Therapy: In instances where toxicity not been a problem, it is recommended that continue therapy using either of the following schedules: Repeat dosage of first course every 30 days after the last day of the previous course.
When toxic signs resulting from the initial course of therapy have subsided, administer a maintenance dosage of 10 to 15 mg/kg/week as a single dose. Do not exceed 1 g per week.
The amount of the drug to be used may vary from 9 to 45 courses of treatment during periods which ranged from 12 to 60 months.