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The oral LD50 of ciclosporin is 2329 mg/kg in mice, 1480 mg/kg in rats and >1000 mg/kg in rabbits. The IV LD50 is 148 mg/kg in mice, 104 mg/kg in rats and 46 mg/kg in rabbits.
No experience of acute overdosage of Sandimmun Neoral is available. Renal dysfunction which would be expected to resolve following drug withdrawal may occur. If indicated, general supportive measures should follow. Elimination can be achieved only by nonspecific measures including gastric lavage, as ciclosporin is not dialyzable to any great extent nor is it cleared well by charcoal hemoperfusion.
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