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Capecitabine is contraindicated in the following patients: Patients with known hypersensitivity to Capecitabine or any of its components.
Patients who have severe renal impairment (Creatinine clearance below 30 ml/min).
Patients with known complete absence of dihydropyrimidine dehydrogenase (DPD) activity.
Patients who concomitantly taking medicine containing Sorivudine or its chemically related analogues such as Brivudine.
Patients who have a history of severe and unexpected reactions to Fluoropyrimidine therapy or with known hypersensitivity to Fluorouracil.
Patient with severe leucopenia, neutropenia, or thrombocytopenia.
During pregnancy and lactation.
Patient with severe hepatic impairment.
If contraindications exist to any of the agents in a combination regimen, that agent should not be used.
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