Sanbelat Drug Interactions

An increased risk of pulmonary toxicity has been described in simultaneous administration of BCNU, mitomycin-C, cyclophosphamide and Methotrexate.
An increase in toxicity of Bleomycin can result from comedication with nephrotoxic substances such as cytostatics (eg. Cisplatin) due to delayed elimination.
There have been reports of a reduced effect of digoxin as a result of diminished oral bioavailibility and a reduction in phenytoin levels in the blood when combined with bleomycin.
Previous or current radiotherapy of the thorax is an important factor to increase the incidence and severity of pulmonary toxicity.
Patients treated with bleomycin are at larger risk of pulmonary toxicity if pure oxygen is administered during an operation. A reduction in the oxygen concentration during and after surgery is recommended.
In patients with a testis carcinoma who are treated with a combination of Bleomycin and vinca-alkaloids, a syndrome has been described which corresponds with Reynaud's disease: Ischemia of the peripheral parts of the body, which may lead to necrosis of these parts (fingers, toes and nose).