Renafos Drug Interactions

Decreased the bioavailability of ciprofloxacin. Sevelamer carbonate should not be taken simultaneously with ciprofloxacin.
Reduced levels of ciclosporin, mycophenolate mofetil and tacrolimus have been occurred in transplant patients when coadministered with sevelamer hydrochloride (i.e. graft rejection). The possibility of an interaction cannot be excluded and a close monitoring of blood concentrations of ciclosporin, mycophenolate, mofetil and tacrolimus should be considered during the use of combination and after its withdrawal.
Hypothyroidism has been occurred in patients with co-administered sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, and levothyroxine. Closer monitoring of thyroid stimulating hormone (TSH) levels is therefore recommended in patients receiving sevelamer carbonate and levothyroxine.
Caution should be exercised when prescribing sevelamer carbonate to patients also taking anti-arrhythmic and antiseizure medicinal products.
Sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, had no effect on the bioavailability of digoxin, warfarin, enalapril, or metoprolol.
Sevelamer carbonate is not absorbed and may affect the bioavailability of other medicinal products. The medicinal product should be administered at least one hour before or three hours after Sevelamer carbonate or the physician should consider monitoring blood levels.