Prevenar 13 Drug Interactions

Children 6 weeks to 5 years of age: Prevenar 13 can be given with any of the following vaccine antigens, either as monovalent or combination vaccines: diphtheria, tetanus, acellular or whole cell pertussis, Haemophilus influenzae type b, inactivated poliomyelitis, hepatitis B, meningococcal serogroup C, measles, mumps, rubella and varicella. Clinical studies demonstrated that the immune responses and the safety profiles of the administered vaccines were unaffected.
Prevenar 13 can also be given concomitantly between 12-23 months of age with the tetanus toxoid conjugated meningococcal polysaccharide serogroups A, C, W and Y vaccine.
Data from a post marketing clinical study evaluating the impact of prophylactic use of antipyretics on the immune response to Prevenar 13 suggest that concomitant administration of paracetamol may reduce the immune response to Prevenar 13 after the infant series. The clinical significance of this observation is unknown.
In clinical trials, where there was concomitant administration of Prevenar 13 and rotavirus vaccine, no change in the safety profiles of these vaccines was observed.
Different injectable vaccines should always be given at different injection sites.
Children and adolescents 6 to 17 years of age: In children and adolescents, there are no data on the concomitant administration of Prevenar 13 with human papillomavirus vaccine (HPV), meningococcal protein conjugate vaccine (MCV4), or tetanus, diphteria and acellular pertussis vaccine (Tdap).
Adults 18 to 49 years of age: No date are currently available regarding concomitant use with other vaccines.
Adults aged 50 years and older: In adults, Prevenar 13 was administered concomitantly with Trivalent influenza vaccine (TIV).
When Prevenar 13 is administered at the same time as another injectable vaccine(s), the vaccines should always be administered with different syringes and given at different injection sites.
Do not mix Prevenar 13 with other vaccines/products in the same syringe.