As an adjunct to diet to reduce hypercholesterolemia & mixed dyslipidemia (Fredrickson types IIa & IIb). To reduce the risk of mortality by reducing coronary death, MI, undergoing revascularization procedures, stroke & to slow progression of coronary atherosclerosis.
Dosage/Direction for Use
Initially 10-20 mg once daily in the evening. Primary hypercholesterolemia w/ a history of liver or kidney dysfunctionElderly Initially 10 mg/day in the evening.
Administration
May be taken with or without food.
Contraindications
Active liver disease or unexplained persistent serum transaminase elevation. Pregnancy & lactation.
Special Precautions
Perform periodic LFTs. History of liver disease. Discontinue use in patients w/ acute myopathy or risk of secondary renal failure due to rhabdomyolysis or elevation of creatinine phosphokinase; not for homozygous familial hypoprolactinemia. Alcoholism. Childn <18 yr.
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