Pantopump Drug Interactions

PANTOPUMP 40 mg may reduce the absorption of drugs whose bioavailability is pH-dependent (e.g. Ketoconazole).
Pantoprazole is metabolized in the liver via the cytochrome P450 enzyme system. An interaction with other drugs or compounds which are metabolized using the same enzyme system cannot be excluded. No clinically significant interactions were, however, observed in specific tests with a number of such drugs or compounds, namely Carbamazepine, Caffeine, Diazepam, Diclofenac, Digoxin, Ethanol, Glibenclamide, Metoprolol, Naproxen, Nifedipine, Phenytoin, Piroxicam, Theophylline, and an oral contraceptive.
Although no interaction during concomitant administration of Phenprocoumon or Warfarin has been observed in clinical pharmacokinetic studies, a few isolated cases of changes in INR have been reported during concomitant treatment in the post-marketing period. Therefore, in patients being treated with coumarin anticoagulants, monitoring of prothrombin time/INR is recommended after initiation, termination or during irregular use of Pantoprazole.
There were also no interactions with concomitantly administered antacids.
Human kinetic interaction studies have been performed administering Pantoprazole concomitantly with the respective antibiotics (Chlarithromycin, Metronidazole, Amoxicyllin). No clinically interactions were found.