Navelbine Injection Caution For Usage

Instruction for use/handling: Handling guidelines: the preparation and administration of Navelbine should be carried out by trained staff. Suitable eye protection, disposable gloves, face mask and disposable apron should be worn. Eventual spillage or leakage should be mopped up.
As with other toxic compounds, caution should be exercised in handling and preparing the solution of Navelbine. Skin reactiins may occur with accidental exposire. The use of gloves is recommended. If the solution of Navelbine contacts the skin or mucosa, immediately wash the skin or mucosa thoroughly with soap and water. It is recommended to infuse Navelbine over 6-10 minutes after dilution in 20-50 ml of normal saline or 5% dextrose solution.
After administration, the vein should be thoroughly flushed with at least 250 ml of isotonic solution.
Navelbine must be given strictly intravenously: it is very important to make sure that the cannula is accurately placed in the vein before starting to infuse Navelbine. If Navelbine extravasates into the surrounding tissue during the administration, considerable local irritation may occur. In this case, the administration should be stopped, the vein flushed with normal saline and the remaining dose administered in another vein. In case of extravasations, to reduce the risk of phlebitis, IV glucocorticoids could be administered immediately.