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Pharmacology: Moxifloxacin is a fluoroquinolone antibacterial. In vitro, moxifloxacin has been shown to have activity against a wide range of Gram-positive and Gram-negative organisms.
The bacterial action of moxifloxacin results from the inhibition with topoisomerase II (DNA gyrase) and IV. Topoisomerases are essential enzymes which play a crucial part in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is also known to influence bacterial chromosome division.
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