Lixiana Dosage/Direction for Use

NVAF: The recommended dose is 60 mg edoxaban once daily with or without food. Therapy with edoxaban in NVAF patients should be continued long term.
DVT & PE: The recommended dose is 60 mg edoxaban once daily following initial use of parenteral anticoagulant for at least 5-10 days with or without food. Duration of therapy (at least 3 months) should be based on risk profile of the patient.
For NVAF and VTE: the recommended dose is 30 mg edoxaban once daily in patients with one or more of the following clinical factors: moderate or severe renal impairment (creatinine clearance (CrCl) 15-50 ml/min), low body weight ≤60 kg and/or concomitant use of the following P-glycoprotein (P-gp) inhibitors: cyclosporine, dronedarone, erythromycin, or ketoconazole.
The 15 mg dose of edoxaban is not indicated as monotherapy and should only be used during a switch from edoxaban to VKA.