Brown pigmentation, especially in patients with mixed iris colors; inflammation of the eyelids, ocular irritation and pain; eyelashes lengthen, grow darker and thicker; conjunctival hyperaemia; transient punctate epithelial erosion; skin rash; less often eyelid edema and rash; rarely dyspnoea, more severe asthma, iritis, uveitis, local edema, darkened palpebral skin.