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Japanese encephalitis vaccine


Generic Medicine Info
Indications and Dosage
Intramuscular
Active immunisation against encephalitis due to Japanese encephalitis virus
Adult: As inactivated, adsorbed vaccine: Primary immunisation: 0.5 mL for 2 doses given 28 days apart. Alternatively, doses may be given 7 days apart as a rapid administration schedule. Booster dose: 0.5 mL as a single dose given between 12-24 months after the primary immunisation, before potential re-exposure to Japanese encephalitis virus. Doses are given via IM inj into the deltoid muscle. Recommendations may vary between individual products or local immunisation guidelines (refer to latest product or country guidelines).
Child: As inactivated, adsorbed vaccine: Primary immunisation: 2 months to <3 years 0.25 mL for 2 doses given 28 days apart; 3-17 years Same as adult dose. Booster dose: 14 months to <3 years 0.25 mL as a single dose given between 12-24 months after the primary immunisation, before potential re-exposure to Japanese encephalitis virus; 3-17 years Same as adult dose. Doses are given via IM inj into the anterolateral aspect of the thigh (2 months to <3 years) or deltoid muscle (3-17 years). Recommendations may vary between individual products or local immunisation guidelines (refer to latest product or country guidelines).

Subcutaneous
Active immunisation against encephalitis due to Japanese encephalitis virus
Adult: Primary immunisation: As live-attenuated vaccine or live-attenuated, recombinant vaccine: 0.5 mL as a single dose. Booster dose: As live-attenuated vaccine: 0.5 mL as a single dose given 3 months to 1 year after the primary immunisation. As live-attenuated, recombinant vaccine: 0.5 mL as a single dose given up to 5 years after the primary immunisation. Doses are given via SC inj into the deltoid region of the upper arm. Recommendations may vary between individual products or local immunisation guidelines (refer to latest product or country guidelines).
Child: >9 months Primary immunisation: As live-attenuated vaccine or live-attenuated, recombinant vaccine: Same as adult dose. Booster dose: As live-attenuated vaccine: Same as adult dose. As live-attenuated, recombinant vaccine: 0.5 mL as a single dose given 12-24 months after the primary immunisation with a live-attenuated vaccine; a single 0.5 mL dose may also be given in children who have previously received an inactivated vaccine, in accordance with the recommendations on the timing for booster doses of inactivated Japanese encephalitis vaccines. Doses are given via SC inj into the anterolateral aspect of the thigh or the deltoid region (9 months to 2 years) or the deltoid region of the upper arm (>2 years). Recommendations may vary between individual products or local immunisation guidelines (refer to specific product or country guidelines).
What are the brands available for Japanese encephalitis vaccine in Indonesia?
Reconstitution
Live-attenuated vaccine: Reconstitute the vaccine using only the supplied diluent and materials. Refer to specific product guidelines for further instructions on reconstitution.
Contraindications
Hypersensitivity. Live, attenuated vaccine: Symptomatic or asymptomatic (with evidence of impaired immunity) HIV infection. Pregnancy and lactation (live, attenuated vaccine). Recommendations for contraindication may vary between available products and between countries (refer to country-specific product guidelines).
Special Precautions
Patient with bleeding disorders (e.g. thrombocytopenia, haemophilia); altered immunocompetence. Patient receiving anticoagulant therapy (IM). Postpone administration in patients with acute severe febrile conditions. Primary immunisation with Japanese encephalitis vaccine should be completed approx 1 week before potential exposure to Japanese encephalitis virus; it is recommended to complete the primary immunisation with only 1 product. Japanese encephalitis vaccine is available in multiple types and given via different routes of administration; verify the product and refer to specific product and local immunisation guidelines prior to administration. Children. Pregnancy and lactation (inactivated, adsorbed vaccine).
Adverse Reactions
Significant: Hypersensitivity or anaphylactoid reactions; syncope, shoulder injury related to IM vaccine administration (e.g. bursitis, tendinopathy).
Ear and labyrinth disorders: Vertigo.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain.
General disorders and administration site conditions: Fatigue, malaise, fever, influenza-like illness, local inj site reactions (e.g. pain, tenderness, redness, hardening, swelling, itching); irritability, crying (particularly in children).
Metabolism and nutrition disorders: Decreased appetite.
Musculoskeletal and connective tissue disorders: Myalgia, arthralgia, musculoskeletal stiffness.
Nervous system disorders: Headache, migraine, dizziness, drowsiness.
Skin and subcutaneous tissue disorders: Rash, pruritus, hyperhidrosis.
Monitoring Parameters
Monitor for syncope and hypersensitivity (including anaphylaxis) for 15-30 minutes after administration.
Drug Interactions
Immunosuppressive treatment (e.g. antimetabolites, alkylating agents, cytotoxic agents, high-dose corticosteroids,) may reduce the immune response to Japanese encephalitis vaccine.
Action
Description:
Mechanism of Action: Japanese encephalitis vaccine induces antibody production to neutralise Japanese encephalitis virus, thus stimulating an active immunity to Japanese encephalitis virus infection.
Onset: Protective immunity: 28 days after the 2nd dose (inactivated vaccine).
Duration: Protective immunity: 12-36 months after initiation of the primary doses (inactivated vaccine).
Storage
Store between 2-8°C. Do not freeze. Protect from light.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07BA03 - encephalitis, Japanese, live attenuated ; Belongs to the class of encephalitis viral vaccines.
J07BA02 - encephalitis, Japanese, inactivated, whole virus ; Belongs to the class of encephalitis viral vaccines.
References
Anon. Japanese Encephalitis Vaccine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 12/07/2024.

Brayfield A, Cadart C (eds). Japanese Encephalitis Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/07/2024.

CD.JEVAX (Chengdu Institute of Biological Products). MIMS Thailand. http://www.mims.com/thailand. Accessed 22/08/2024.

Imojev Powder and Diluent for Suspension for Injection (Global Biotech Products Co., Ltd.). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 22/08/2024.

Ixiaro Suspension for Injection (Valneva Austria GmbH). MHRA. https://products.mhra.gov.uk. Accessed 12/07/2024.

Ixiaro, Inactivated, Adsorbed Injection, Suspension (Valneva Scotland Ltd.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 12/07/2024.

Japanese Encephalitis Virus Vaccine (Inactivated). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 12/07/2024.

Japanese Encephalitis Virus Vaccine (Live/Attenuated). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 12/07/2024.

Joint Formulary Committee. Japanese Encephalitis Vaccine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/07/2024.

Seqirus (NZ) Ltd. Jespect, Suspension for Injection data sheet 9 February 2021. Medsafe. http://www.medsafe.govt.nz. Accessed 12/07/2024.

Disclaimer: This information is independently developed by MIMS based on Japanese encephalitis vaccine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com
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