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Heparin therapy should be monitored carefully to reduce the risk of overdosage, haemorrhage and serious adverse reactions such as delayed onset thrombocytopenia.
Risk factors for haemorrhage may include IM injections, trauma, recent surgery, women over 60 years, malignancy, peptic ulcer disease, potential bleeding sites and acquired or congenital homeostatic defects.
As heparin is derived from animal tissue (bovine mucous), it should be used with caution in patients with a history of allergy. Before a therapeutic dose is given to such a patient, a trial dose of 1000 units may be advisable.
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