Gardasil Drug Interactions

In all clinical trials, individuals who had received immunoglobulin or blood-derived products during the 6 months prior to the 1st vaccine dose were excluded.
Use with Other Vaccines: Administration of Gardasil at the same time (but, for injected vaccines, at a different injection site) as hepatitis B (recombinant) vaccine did not interfere with the immune response to the HPV types. The seroprotection rates (proportion of subjects reaching seroprotective level anti-HBs >10 mIU/mL) were unaffected (96.5% for concomitant vaccination and 97.5% for hepatitis B vaccine only). Anti-HBs geometric mean antibody titres were lower on co-administration but the clinical significance of this observation is not known.
The concomitant administration of Gardasil with vaccines other than hepatitis B (recombinant) vaccine has not been studied.
Use with Hormonal Contraceptives: In clinical studies, 57.5% of women (age 16-26 years) who received Gardasil used hormonal contraceptives. Use of hormonal contraceptives did not appear to affect the immune response to Gardasil.
Incompatibilities: In the absence of compatibility studies, Gardasil must not be mixed with other medicinal products.