Concurrently treat male partner where there is evidence of trichomonal infection in the male consort. Discontinue therapy when irritation occurs. Used after careful benefit-risk assessment in patients w/ severe hepatotoxicity/acute hepatic failure, including Cockayne syndrome. Patients w/ severe cutaneous adverse reactions (SCARs) including SJS & acute generalized exanthematous pustulosis (AGEP). Should not be given during the 1st trimester of pregnancy. Only to be used as palliative therapy in the 2nd & 3rd trimester of pregnancy.
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