Flagyl/Flagyl Forte Drug Interactions

Flagyl Suspension/Flagyl Forte: Disulfiram: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia).
Oral anticoagulant therapy (warfarin type): Potention of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of coadministration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.
Vecuronium (non-depolarising neuromuscular blocking agent) potentiates the action of vecuronium.
Flagyl may be given alone. In combination with other antibiotic given in full normal therapeutic doses. metronidazole both should be.
Cimetidine prolongs the plasma clearance of metronidazole, presumably by inhibiting metabolic enzymes, toxic concentrations of metronidazole may be produced.
Lithium: Plasma levels of lithium may be increased by metronidazole. Plasma concentration of lithium, creatinine and electrolytes should be monitored in patients under treatment with lithium while they receive metronidazole.
Ciclosporin: Risk of elevation of ciclosporin serum levels. Serum ciclosporin and serum creatine should be closely monitored when coadministration is necessary.
Phenytoin or Phenobarbital: Increased elimination of metronidazole resulting in reduced plasma levels.
5 Fluorouracil: Reduced clearance of 5 fluorouracil resulting in increased toxicity of 5 fluorouracil.
Busulfan: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.
Flagyl Suspension: Metronidazole may immobilize treponema and hence result in a falsely positive treponema pallidum immobilization test.
In order to prevent possible interactions you must inform physician or pharmacist about the current treatment.
Flagyl Suppository: FLAGYL may be given alone. In combination with other antibiotic: both should be given in full normal therapeutic doses.
Prior to simultaneous administration with warfarin, the anticoagulant should be checked and if possible to be suitably reduced.
Cimetidine prolongs the plasma clearance of metronidazole, presumably by inhibiting metabolic enzymes, toxic concentrations of metronidazole may be produced.
Metronidazole reduces the clearance of 5-fluorouracil and can therefore result in increased toxicity of 5-fluorouracil.
Plasma levels of busulfan may be increased by metronidazole which may lead to severe busulfan toxicity.
Flagyl Forte: It is recommended to use metronidazole as single drug. In combination with other antibiotic, both should be given in a full dose for normal therapy Cimetidine might prolonged metronidazole plasma clearance which lead to toxic concentration of metronidazole.
Psychotic reaction has been reported when concomitant metronidazole, disulfiram and alcohol was taken simultaneously.