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Farmalat ER must not be used in cases of known hypersensitivity to nifedipine or to any of the excipients. Nifedipine is contraindicated in pregnancy before week 20 and during breastfeeding. Farmalat ER must not be used in cases of cardiovascular shock. Farmalat ER must not be used within the first 8 days after an acute episode of myocardial infraction. Nifedipine must not be used in combination with rifampicin because no efficient plasma levels of nifedipine may be obtained due to enzyme induction. Farmalat ER must not be used in patients with kock pouch (ileostomy after proctocolectomy).
Fertility: In single cases fertilization calcium antagonists like nifedipine have been associated with reversible biochemical changes in the spermatozoa's head section that may result in impaired sperm function. In those men who are repeatedly unsuccessful in fathering a child by in-vitro fertilization, and where no other explanation can be found, calcium antagonists like nifedipine should be considered as possible causes.
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