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Indications and Dosage
Topical/Cutaneous
Acne vulgaris Adult: Each mL of cutaneous solution contains erythromycin 40 mg and zinc acetate 12 mg
Apply to the affected area bid for 10-12 weeks. Child: Same as adult dose. |
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Contraindications
Hypersensitivity to erythromycin, zinc acetate, or other macrolide antibiotics.
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Special Precautions
Children. Pregnancy and lactation.
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Adverse Reactions
Significant: Rarely, serious allergic reactions including acute generalised exanthematous pustulosis (AGEP).
Skin and subcutaneous tissue disorders: Dry skin, pruritus, erythema, skin irritation, skin burning sensation, skin exfoliation. |
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Patient Counseling Information
Avoid contact with eyes or mucous membranes of the nose and mouth.
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Action
Description:
Mechanism of Action: Erythromycin exhibits its antibacterial activity by inhibiting RNA-dependent protein synthesis at the chain elongation step. It binds to the 50S ribosomal subunit of susceptible bacteria, thereby blocking transpeptidation. Zinc acetate is solubilised by forming a complex with erythromycin and aids in the wound healing process. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 12560, Erythromycin. https://pubchem.ncbi.nlm.nih.gov/compound/Erythromycin. Accessed Aug. 22, 2023.  Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 11192, Zinc Acetate. https://pubchem.ncbi.nlm.nih.gov/compound/Zinc-Acetate. Accessed Sept. 24, 2024. |
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Storage
Store at or below 25°C.
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MIMS Class
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ATC Classification
D10AF52 - erythromycin, combinations ; Belongs to the class of topical antiinfective preparations used in the treatment of acne.
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References
Erythromycin (Topical). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/09/2024. Erythromycin and Zinc Acetate. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/09/2024. Joint Formulary Committee. Erythromycin with Zinc Acetate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/09/2024. Zineryt 40 mg + 12 mg Powder and Solvent for Cutaneous Solution (Neon Healthcare Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 04/09/2024.
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