Endoxan Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info

Concise Prescribing Info

Contents

Cyclophosphamide

Indications/Uses

Carcinomas, leukemia, lymphogranulomatosis, sarcomas, lymphosarcomas, reticulum cell sarcoma, multiple myeloma. Mammary & ovarian carcinoma.

Dosage/Direction for Use

IV inj After satisfactory remission has occurred, maintenance w/ tab is recommended. Initially 3-6 mg/kg daily, or massive-intermittent therapy w/ 10-15 mg/kg, w/ therapy-free interval of 2-5 days, or massive-intermittent therapy w/ 20-40 mg/kg, w/ therapy-free interval of 21-28 days.

Contraindications

Severely impaired bone marrow function (particular in patients pre-treated w/ cytotoxic agents &/or RT); inflammation of bladder (cystitis), urinary outflow obstructions, active infections. Pregnancy & lactation.

Special Precautions

Patients of reproductive age should use contraceptives throughout therapy & for not <6 mth afterwards. DM. Renal & hepatic failure. Elderly & debilitated patients.

Adverse Reactions

GI upsets; alopecia; reticulo-endothelial system depression; hematuria; reversible amenorrhea & azoospermia; myocardial damage w/ very high doses; pigmentation, macrocytosis, water retention; induction of hyperglycemia or hypoglycemia; risk of secondary malignancies.

View ADR Reporting Link

Drug Interactions

May potentiate hypoglycemic effects of sulfonylureas. Allopurinol (increased incidence of bone marrow depression). Suxamethonium (prolongation of apnoea).

MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01AA01 - cyclophosphamide ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

Endoxan powd for inj 1000 mg

Packing/Price

1's (Rp783,300/vial)

Form

Endoxan powd for inj 200 mg

Packing/Price

1's (Rp232,500/vial)

Form

Endoxan powd for inj 500 mg

Packing/Price

1's (Rp517,000/vial)

Endoxan

cyclophosphamide

Manufacturer:

Transfarma Medica Indah

Marketer:

A Menarini