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Prolonged, excessive use over large surface area may augment systemic absorption which may result in symptoms and sign of corticosteroid excess (Adrenal suppression, Cushing's syndrome, hyperglycemia, and hypertension).
Long-term and intensive treatment with high potency corticosteroid preparations may cause local atrophic changes, e.g. thinning of the skin, striae, and dilatation of superficial blood vessels particularly when occlusive dressings are used or when skin folds are involved.
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