Diutensi

Edema caused by heart disease, hepatic & kidney impairment. Tab: Peripheral edema due to mechanical obstruction, venous insufficiency, HTN. Inj: Adjunctive therapy in acute pulmonary & cerebral edema.

Tab Edema Adult Initially 20-80 mg as single dose. Dose increments of 20-40 mg may be made not sooner than 6-8 hr after previous dose to achieve the desired diuretic effect. Max dose: Not >600 mg daily. Childn Initially 1-2 mg/kg as single dose, may be increased by 1-2 mg/kg not sooner than 6-8 hr after previous dose until the desired effect is achieved. Max dose: Not >6 mg/kg. HTN Adult Initially 80 mg, usually divided into 40 mg twice daily. Additional antihypertensive agents may be added if the desired response is not achieved. IV Inj rate not exceeding 4 mg/min. Adult & adolescent ≥15 yr 20-40 mg once or twice daily, may be added 20 mg every 2 hr. Acute pulmonary edema 40 mg, may be increased to 80 mg slowly. Cerebral edema 20-40 mg 3 times daily. Forced diuresis 20-40 mg adjunctive to electrolyte infusion. Infant & childn <15 yr 1 mg/kg. Max: 20 mg daily.

Should be taken on an empty stomach: If GI distress occurs, take w/ food or milk.

Hypersensitivity to furosemide & sulfonamide. Anuria, electrolyte deficiency eg, hypokalemia or hyponatremia, hepatic coma, hypovolemia w/ or w/o hypotension. Kidney failure. Pregnancy & lactation.

Patients w/ hypotension, DM, latent diabetes or manifestations of diabetes, hepatorenal syndrome. Tab: Patients at high risk of severe BP reduction, electrolyte imbalance & high fluid loss due to vomiting, diarrhea or excessive sweating. Gout. Decreased protein blood levels in nephrotic syndrome (hypoproteinemia). May cause temporary increase in free thyroid hormone followed by decrease in total thyroid hormone levels. Correct hypokalemia, hyponatremia, hypovolemia & dehydration before treatment. Closely monitor dehydration & thyroid hormone levels. Concomitant use w/ risperidone. Pregnancy, lactation. Premature infants. Inj: Prostate hypertrophy, ureterostenosis, hydronephrosis.

Tab: Hemoconcentration, thrombocytopenia, eosinophilia, leukocytopenia, hemolytic anemia, aplastic anemia, agranulocytosis; skin allergies, SC tissue disorders, anaphylaxis; electrolyte imbalances, dehydration, hypovolemia, hyponatremia, hypokalemia, hypochloremia, increased uric acid & cholesterol, hyperglycemia; hepatic encephalopathy, paresthesia; hearing loss, tinnitus; hypotension, including orthostatic hypotension, vasculitis; nausea, vomiting, diarrhea, acute pancreatitis; hepatobiliary disorders; increased blood creatinine level & urine vol, tubulointerstitial nephritis; dizziness. Inj: Insomnia, headache, excitation, tremor, tachycardia, arrhythmia, palpitation, difficulty in urination.

Concomitant use w/ phenytoin, antihypertensives, probenecid. Tab: Concomitant use w. glucocorticoids, carbenoxolone, laxatives, NSAIDs (indomethacin, ASA), MTX, diuretics, other BP-lowering medications, cyclosporine A. Inj: Concomitant use w/ aminoglycosides, cisplatin, nephrotoxic antibiotics, salicylate & lithium.

Diuretics

C03CA01 - furosemide ; Belongs to the class of high-ceiling sulfonamide diuretics.

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