Diflorasone: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses

Adult: As 0.05% oint/cream: Apply a thin film onto the affected areas 1-4 times daily depending on the severity of the condition.

Contraindications

As treatment for rosacea or perioral dermatitis.

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Significant: HPA axis suppression, manifestations of Cushing’s syndrome, hyperglycaemia, and glycosuria.
Dermatologic: Itching, burning, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration, atrophy, striae, miliaria, secondary infections.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Do not apply on the face, eyes, mucous membranes, intertriginous areas, occluded or broken skin, and into a large surface area.

Monitoring Parameters

Monitor for hypothalamic-pituitary adrenal (HPA) axis suppression through ACTH stimulation test, plasma cortisol test, or urinary free cortisol test.

Action

Description:
Mechanism of Action: Diflorasone is a glucocorticoid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A₂ inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators.
Pharmacokinetics:
Absorption: Absorbed through normal intact skin (approx 1%); increased percutaneous absorption in inflamed or occluded skin.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Topical Corticosteroids

ATC Classification

D07AC10 - diflorasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.

References

Anon. Diflorasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/02/2017.

Buckingham R (ed). Diflorasone Diacetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/02/2017.

Diflorasone Diacetate Cream (E. Fougera & Co. A division of Fougera Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/02/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Dilforasone Diacetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 16/02/2017.

Disclaimer: This information is independently developed by MIMS based on Diflorasone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com