Dexmeto Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Dexmedetomidine HCl

Indications/Uses

Sedation of initially intubated & mechanically ventilated patients during treatment in ICU.

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Dosage/Direction for Use

Individualized & titrated to desired clinical effect. Adult Loading infusion: 1 mcg/kg over 10 min, followed by maintenance infusion of 0.2-0.7 mcg/kg/hr, adjusted to achieve desired level of sedation. Renal & hepatic impairment Dosage reductions should be considered.

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Overdosage

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Warnings

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Special Precautions

Not indicated for infusions lasting >24 hr. Continuously monitor patient during administration. Patients w/ advanced heart block &/or severe ventricular dysfunction. Hypotension &/or bradycardia may be more pronounced in patients w/ hypovolemia, DM or chronic HTN. Co-administration w/ other vasodilators or -ve chronotropic agents; amphotericin B, diazepam. Transient HTN. Not to be co-administered through same IV catheter w/ blood, serum or plasma. May produce clonidine-like withdrawal syndrome upon abrupt discontinuation. Not to be administered for >24 hr. Hepatic & renal impairment. Pregnancy & lactation. Not recommended during labor & delivery including cesarean section. Not recommended in ped patients <18 yr. Elderly ≥65 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypotension, HTN, nausea, bradycardia, fever, vomiting, hypoxia, tachycardia & anemia. Hyperpyrexia, hypovolemia, light anesth, pain, rigors; BP fluctuation, heart disorder, aggravated HTN; dizziness, headache, neuralgia, neuritis, speech disorder; abdominal pain, diarrhea; arrhythmia, ventricular arrhythmia & tachycardia, AV & heart block, cardiac arrest, extrasystoles, atrial fibrillation, T wave inversion, supraventricular tachycardia; increased GGT, SGOT, SGPT; acidosis, resp acidosis, hyperkalemia, increased alkaline phosphatase, thirst; agitation, confusion, delirium, hallucination, illusion; apnea, bronchospasm, dyspnea, hypercapnia, hypoventilation, pulmonary congestion; increased sweating; photopsia, abnormal vision.

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Drug Interactions

Enhanced effects w/ anesth, sedatives, hypnotics, opioids, sevoflurane, isoflurane, propofol, alfentanil, midazolam.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Hypnotics & Sedatives

ATC Classification

N05CM18 - dexmedetomidine ; Belongs to the class of other hypnotics and sedatives.

Regulatory Classification

Presentation/Packing

Form

Dexmeto inj 100 mcg/mL

Packing/Price

(vial) 2 mL x 5 × 1's

Dexmeto

dexmedetomidine

Manufacturer:

Fahrenheit