Dermades

Each gram of cream/ointment contains Desonide 0.5 mg.

As other corticosteroids, Desonide has topical anti inflammatory and steroid topical characteristics. The mechanism of action on how a topical steroid posseses an anti-inflammatory effect, is generaly unclear. It is predicted that corticosteroid may act through induction of phospholipase-A2 inhibitory proteins, collectively known as lipocortin. It is postulated that these proteins control the biosynthesis of inflammatory mediators such as prostaglandin and leucotrienes by inhibiting the release of their precursor (i.e. Arachidonic acid) from membrane phospholipids by phospholipase-A2.

Dermatitis, atopic dermatitis, contact dermatitis, and various forms of dermatitis, pruritus, urticaria, and psoriasis.

Apply a thin film to the affected area two to four times daily.

Patients who are hypersensitive to Desonide and any other components of this preparations.
Patients with viral infection of the skin (vaccinia, herpes simplex, varicella), skin tuberculosis, and rosacea.

It is not for ophthalmic use.
Use with caution in pregnant and nursing women.
Discontinue application if irritation or sensitization occurs, and appropriate therapy should be administered.
If dermatologic infections develop, this preparation should be administered in combination with appropriate antibacterial or antifungal agent. If the treatment hasn't shown any benefit, discontinue application until infection has been adequately controlled.
Use in infant and children may cause adrenal suppresion.
Systemic absorption of topical corticosteroid will be increased if extensive body surface areas are treated or if occlusive dressing is used. Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamus-pituitary axis suppression and Cushing's syndrome than adult patients because of a larger skin surface area to body weight ratio. Chronic corticosteroid therapy may interfere with growth and development of children.
Corticosteroid therapy is applied only if any other less toxic drug is not effective.

The following local adverse reactions have been reported infrequently with the use of topical corticosteroids: burning sensation, itching, irritation, dry skin, folliculitis, hypertrichosis, acneiform eruption, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae, and miliaria.

Store below 30°C.

Topical Corticosteroids

D07AB08 - desonide ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.

K