Experience with overdose of dasatinib in clinical studies is limited to isolated cases. The highest overdose of 280 mg per day for one week was reported in two patients and both developed a significant decrease in platelet counts. Since dasatinib is associated with grade 3 or 4 myelosuppression (see Precautions), patients who ingest more than the recommended dose should be closely monitored for myelosuppression and given appropriate supportive treatment.