Cyclophosan Adverse Reactions

Nausea and vomiting may occur. Loss of hair is relatively common. The most serious side effect is bone marrow depression (leukopenia, thrombocytopenia). Because of this, the white blood cell count (and possibly also the number of thrombocytes) should be controlled sufficiently often during the treatment. Usually a control performed once a week or once every two weeks is adequate. With a small dosage, a control performed less frequently may be sufficient, if the white blood cell count is stable. The control of thrombocytes is necessary only when the number of leukocytes is low.
Other possible side effects include amenorrhea, azospermia and sterile haemorrhagic cystitis. Cystitis can be avoided by large amounts of liquid.
Alopecia; Bladder fibrosis and carcinoma have been reported after long term use of cyclophosphamide; Liver disfunction; Hyperpigmentation; Oral ulceration.